Figure 1: Schematic of RAG-mediated DNA binding and cleavage. Here we report the crystal structure of the mouse RAG1 NBD in complex with a 14-mer DNA molecule containing the nonamer. The NBD adopts an ...
The discovery of DNA structure by James Watson and Francis Crick in the year 1953 is one of the most revolutionary scientific discoveries to date. However, the research leading to the discovery of ...
Researchers have developed a new fluorescent label that gives a clearer picture of how DNA architecture is disrupted in cancer cells. The findings could improve cancer diagnoses for patients. Their ...
Nuclear hormone receptors (NRs) are ligand-inducible transcription factors that regulate diverse physiological processes and are major drug targets in disease 1,2,3. The NRs are conserved multidomain ...
A new study published in Nature Structural & Molecular Biology reveals how the fundamental enzyme called DNA polymerase delta operates during DNA replication, making a copy of the genetic code that ...
James Watson and Francis Crick proposed that DNA (deoxyribonucleic acid) was a double-helix structure, not a triple stranded structure as had been previously hypothesized, on April 2, 1953. The ...
In the middle of the 20th century, accumulating data suggested that DNA carries life’s genetic information. Biochemists around the world raced to determine its structure. The competition led to some ...
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